Advanced Surgical Options for Epilepsy

Surgery for epilepsy?

Yes, it’s true — there are surgical options for epilepsy. In fact, in carefully selected patients as many as 80 percent can be cured of seizures entirely. In other cases surgery may reduce the frequency and severity of seizures.

Epilepsy surgery is a complex procedure that starts with localizing the seizures to determine the precise spot in the brain where they originate. Localizing is followed by brain mapping to determine what functional areas of the brain may be affected by surgery. The surgery itself is a complex procedure requiring a highly skilled, experienced neurosurgeon.

Neurosurgeons who specialize in epilepsy surgery can cure epilepsy by removing the source of the epilepsy within the brain.  The surgeon must open the skull, performing what is called a “craniotomy,” but in skilled hands the risks of this procedure are quite low.  In special circumstances other procedures — such as lesionectomy, hemispherectomy, and corpus callosotomy — can be performed to treat different types of seizure disorders. The variety of surgical approaches mandates that a neurosurgeon specializing in epilepsy perform your surgery to achieve the best possible outcome.


There are several techniques available for controlling seizures that do not offer the possibility of cure but can dramatically reduce seizure frequency and severity with minimal risks. Vagal nerve stimulation (VNS) responsive neurostimulation (RNS), and deep brain stimulation (DBS) are less invasive surgical options for controlling epilepsy. They all use an implanted device, similar to a pacemaker, to send signals to the brain to prevent seizures.

• VNS works by sending regular, mild pulses of electrical energy to the brain via the vagus nerve.
• RNS works by recording from and stimulating the brain directly in order to predict and interrupt seizures before they start.
• DBS stimulates deep brain structures involved in the seizure and prevents seizures from occurring.

Laser Surgery
Laser interstitial thermal therapy (LITT) is an advanced new option that uses tiny beams of light to heat a seizure-provoking lesion and destroy it—without damaging surrounding healthy brain tissue and without subjecting patients to the potential side effects of radiation. This procedure represents the very latest generation of minimally invasive neurosurgery, as it requires only a very small opening in the skull to allow the neurosurgeon to insert the laser. (More about laser surgery for epilepsy)

Deep Brain Stimulation
In DBS, a device is implanted in the chest below the collar bone and delivers electrical stimulation over tiny wires to the anterior nucleus of the thalamus (ANT), interrupting the propagation of seizures. The electrodes can be directed to very specific points in the brain, which is why this process works on multiple conditions; different parts of the brain can be stimulated to relieve the symptoms of Parkinson’s disease, essential tremor, and now epilepsy. (More about DBS for epilepsy)

Focused Ultrasound
Focused ultrasound uses MRI guidance to focus an array of 1,000 ultrasound waves on a precise location in the brain. Each beam is so small and low-energy that it passes harmlessly through healthy brain tissue, but the sum of the energy reaching the focus is enough to obliterate its target. It is FDA-approved for treating essential tremor, and Weill Cornell recently became the first in New York to offer it. It is currently considered experimental for epilepsy.  (More about image-guided focused ultrasound)


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Weill Cornell Medicine Neurological Surgery 525 East 68 Street, Box 99 New York, NY 10065 Phone: 866-426-7787