Surgery for a Craniopharyngioma

Endoscopic endonasal approach to skull base tumorsThe goal of surgery for a craniopharyngioma is to remove as much of the tumor as possible without damaging nearby structures or causing neurological damage. However, in many patients the tumor has already, or will soon, damage pituitary function, in which case the surgeon may decide to remove the pituitary gland and stalk in order to cure the tumor to avoid the possibility of recurrences. All hormones made by the pituitary gland can be replaced with medications and one can live a healthy normal life without a functioning pituitary gland. Surgery is complicated by the way tumor invades healthy brain tissue — removing the entire tumor may cause permanent damage, but leaving some of the tumor behind increases the risk of the tumor’s recurrence. The decision as to the best surgical goals must be made by the patient, their family and the surgeon together after discussing the pros and cons of each alternative.

The surgery may be open surgery, in which a neurosurgeon removes a portion of the skull to gain access to the tumor, or a less invasive endoscopic surgery, in which the surgeon approaches the tumor through the nose, which is the most common approach used in most major centers. Weill Cornell was one of the first centers to use this approach and now has more experience than almost any other center in the world. Whether or not the patient is a good candidate for minimally invasive “endonasal” surgery depends on the location and size of the tumor as well as the experience and skill of the neurosurgeon. In some situations an endoscopic surgery can be done through a small bur hole at the top of the head to drain large cysts, sometimes associated with craniopharyngiomas. Neurosurgeons with advanced training in endoscopic techniques are best qualified to perform these procedures. (Read more about our minimally invasive Skull Base Surgery Program.)

If the tumor cannot be completely removed during surgery, the patient may have radiation therapy as a follow-up to kill off any remaining tumor cells to help prevent recurrence. Radiation is known to have long-term effects on growth and development, so it is not the best choice for children (although it may sometimes be necessary).

Some craniopharyngiomas may be treated using stereotactic radiosurgery (SRS). Commonly known as Gamma Knife or CyberKnife, stereotactic radiosurgery is not surgery in the conventional sense, but rather uses highly focused beams of radiation to destroy the tumor. (Read more about our Stereotactic Radiosurgery Program.)

If the tumor can be completely removed, the chances of a complete cure are very good. Patients may need long-term hormone treatments after surgery, but most return to full and active lives after treatment. In some cases, there will be some neurological deficits caused by the tumor or by the surgery to remove it.

Since craniopharyngiomas may regrow after treatment, patients will have ongoing MRI or CT scans to watch for the tumor’s return. If there is a recurrence, it’s most likely to happen in the first two years after surgery.

A craniopharyngioma is a complicated tumor that is best treated at a major medical center by a neurosurgeon with advanced skills and experience in treating craniopharyngiomas (See Doctors Who Treat Craniopharyngiomas).

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Our Care Team

  • Chair and Neurosurgeon-in-Chief
  • Margaret and Robert J. Hariri, MD ’87, PhD ’87 Professor of Neurological Surgery
  • Vice Provost of Business Affairs and Integration
Phone: 212-746-4684
  • Vice Chair for Clinical Research
  • David and Ursel Barnes Professor of Minimally Invasive Brain Surgery
  • Professor of Neurosurgery, Neurology, and Otolaryngology
  • Director, Center for Epilepsy and Pituitary Surgery
  • Co-Director, Surgical Neuro-oncology
Phone: 212-746-5620
  • Assistant Professor of Neurological Surgery
  • Leon Levy Research Fellow
  • Feil Family Brain and Mind Research Institute
Phone: 646-962-3389
  • Associate Professor of Neuroendocrinology in Neurological Surgery, Weill Cornell Medicine
Phone: 646-962-3556
  • Vice Chair for Academic Affairs
  • Professor of Neurological Surgery, Pediatric Neurosurgery
  • Associate Residency Director
Phone: 212-746-2363
  • Director, Neurosurgical Radiosurgery
  • Professor of Clinical Neurological Surgery
Phone: 212-746-2438
  • Chief of Neurological Surgery, NewYork-Presbyterian Queens
  • Professor of Clinical Neurological Surgery
  • Co-director, Weill Cornell Medicine CSF Leak Program
Phone: (718) 670-1837
  • Chief of Neurological Surgery, NewYork-Presbyterian Brooklyn Methodist
  • Professor, Neurological Surgery
  • Director, Brain Metastases Program
  • Co-director, William Rhodes and Louise Tilzer-Rhodes Center for Glioblastoma
Phone: 212-746-1996 (Manhattan) / 718-780-3070 (Brooklyn)
  • Vice Chair, Neurological Surgery
  • Director, Pediatric Neurological Surgery
Phone: 212-746-2363
  • Associate Professor of Clinical Neurological Surgery
Phone: 718-780-5176

Reviewed by: Theodore Schwartz, M.D.
Last reviewed/last updated: September 2023
Illustration by Matt Holt

Weill Cornell Medicine Neurological Surgery 525 East 68 Street, Box 99 New York, NY 10065 Phone: 866-426-7787