Symptoms of Acromegaly

Visible symptoms of acromegaly may include:

  • Enlarged hands and feet
  • Changes in facial appearance (widening or protruding features, enlarged lips or tongue, spaces between teeth)
  • Skin changes (skin tags, thickening skin, excess perspiration, body odor)
  • Voice changes (deep or hoarse voice)
  • Hair growth
  • Weight gain

Other symptoms and conditions secondary to the excess of growth hormone (GH) may include:

  • Headache
  • Fatigue and weakness
  • Joint pain or limited joint movement
  • Vision changes
  • Decreased libido, erectile dysfunction
  • Changes in menstrual cycle
  • Sleep apnea
  • Diabetes (high blood sugar)
  • High blood pressure

Many people who experience some or all these individual symptoms as well as many of their treating medical professionals do not realize that they are related, so diagnosing acromegaly is usually delayed. The patient or a sharp-eyed primary care physician may be the first to recognize the connections between a wider shoe size, menstrual changes, and vision problems. Whenever acromegaly or other hormone-related conditions are suspected, the patient should be referred for testing and definitive diagnosis. (See Diagnosing and Treating Acromegaly.)

Patients diagnosed with a pituitary tumor should be referred to a major medical center with an expert team of pituitary specialists. At Weill Cornell Medicine Neurological Surgery, patients will be evaluated by a multi-disciplinary team that includes neurosurgeons, endocrinologists, otolaryngologists, and neuroradiologists. If surgery is recommended, it will be performed by a neurosurgeon with advanced skills in minimally invasive procedures to remove pituitary tumors. (See Surgery for a Pituitary Tumor.)

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Our Care Team

  • Vice Chair for Clinical Research
  • David and Ursel Barnes Professor of Minimally Invasive Brain Surgery
  • Professor of Neurosurgery, Neurology, and Otolaryngology
  • Director, Center for Epilepsy and Pituitary Surgery
  • Co-Director, Surgical Neuro-oncology
Phone: 212-746-5620
  • Assistant Professor of Neurological Surgery
  • Leon Levy Research Fellow
  • Feil Family Brain and Mind Research Institute
Phone: 646-962-3389
  • Associate Professor of Neuroendocrinology in Neurological Surgery, Weill Cornell Medicine
Phone: 646-962-3556
  • Director, Neurosurgical Radiosurgery
  • Professor of Clinical Neurological Surgery
Phone: 212-746-2438
  • Chief of Neurological Surgery, NewYork-Presbyterian Brooklyn Methodist
  • Professor, Neurological Surgery
  • Director, Brain Metastases Program
  • Co-director, William Rhodes and Louise Tilzer-Rhodes Center for Glioblastoma
Phone: 212-746-1996 (Manhattan) / 718-780-3070 (Brooklyn)

Reviewed by: Georgiana Dobri, M.D.
Last reviewed/last updatedSeptember 2023

Weill Cornell Medicine Neurological Surgery 525 East 68 Street, Box 99 New York, NY 10065 Phone: 866-426-7787